The 5 Depression Biotypes

Updated: Jul 6


Depression is a major health crisis in America and getting worse by the day thanks to COVID-19. For many people living with depression, drugs that are supposed to help them get better often come with unpleasant side effects and can even make their symptoms worse.


Make no mistake about it: depression is big business. The sicker people there are, and the longer they stay sick, the more money drug makers make. This is good news for the pharmaceutical industry, but bad news for people struggling with mental health.


Antidepressants don't cure depression because they’re not designed to cure it, just treat the symptoms. In the 1970s, researchers really started to look at chemical imbalances in the brain and ways to improve brain function. This led to the treatment options you see advertised on TV today: drugs like Lexapro, Paxil, and Zoloft. These drugs treat the symptoms of depression - like low levels of serotonin or dopamine – but ignore the root causes behind why those levels are off in the first place.


Imagine the brain as a garden whose plants are sickly and fail to flourish. The way we treat depression is like spraying on a bunch of fertilizer without first checking the quality of the soil. But as everybody knows, nothing grows well in poor soil.


Around the same time that the pharmaceutical industry really got moving, a biochemist named Dr. William Walsh started wondering whether people with depression were biochemically different from people without depression. Over the next several decades, Dr. Walsh’s groundbreaking research proved his theory right: depressed people are biochemically different from non-depressed people.


Dr. Walsh discovered people with depression can be categorized into five major biotypes, each having distinct symptoms of depression and responding differently to psychiatric medications.


#1 - Under-methylation

The first depression biotype is undermethylation, which is an abnormally low methyl-to-folate ratio. People with this biotype have classic symptoms of depression such as low serotonin and dopamine and generally respond well to psychiatric medications.

#2 - Folate deficiency

The second biotype is folate deficiency and as the name suggests, people with this biotype have too-low levels of folate. Their depression symptoms are distinct: anxiety, panic disorder, and intolerance to selective serotonin reuptake inhibitors (SSRI’s) and antihistamines.

When people with this biotype take SSRIs, their depression gets worse and they may even become violent.


#3 - Hypercupremic

The third biotype is hypercupremic, or elevated copper. The vast majority (96%) of people with copper overload are women. People with this biotype have other symptoms such as severe anxiety, sleep disorders, hormone imbalances, skin sensitivity to metals, and psychosis, in addition to the classic symptoms of depression.


#4 - Pyroluric

The fourth biotype is pyroluric. People with this biotype are deficient in zinc and vitamin B-6 perhaps genetically which results in low levels of serotonin, dopamine, and GABA neurotransmitters. They also can experience odd combinations of symptoms including severe mood swings, rages, morning nausea, and sensitivity to bright lights and loud noises.

#5 - Toxic overload

The fifth biotype is toxic overload. Lead, mercury, arsenic, or cadmium overload affects 1 in 500 Americans. This kind of depression comes on suddenly and seemingly out of nowhere.

People have symptoms like abdominal pain and cramping, headaches, muscle weakness, low energy, and they generally do not respond to psychiatric medications.



If you or someone you love is being treated for depression but have never been checked for things like abnormal folate and copper levels, you can thank Big Pharma. They have done a great job of cornering the market and burying the research of people like Dr. William Walsh.


Make no mistake, the American medical system is a for-profit business. The sicker you are, the more valuable you are to drug makers.


This topic hits awfully close to home for me. My daughter has struggled for years with her mental health. Therapy and medications have helped manage her symptoms (anxiety, panic attacks, poor sleep, depression) but only a point. A few weeks ago, she went to a doctor who is certified in Dr. Walsh’s nutrient therapy protocol for some bloodwork. She discovered her copper levels are three times what they should be. She’s now started treatment to de-copper her body and, hopefully, find freedom from depression.


It is just astonishing that – considering her symptoms – none of her doctors ever ordered bloodwork to check her copper-zinc ratio. While it’s definitely too early in the process to claim victory, she’s just happy that something makes sense and that a cure might actually be possible.


If you are sick and tired of being sick and tired – and being a cash cow for the pharmaceutical industry – pick up a copy of Nutrient Power by Dr. William Walsh. He has worked with over 30,000 patients with conditions ranging from depression to autism and ADHD to Alzheimer’s.


There are other treatment options besides big pharma, but it’s up to you to find them.

The system is set up to keep you sick. Becoming an informed consumer of your health just might set you free.


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